Uracil is an organic base, one of the four main bases in RNA, a major pyrimidine component in ribonucleic acid, and a constituent of various uridylates. By connecting with ribose through nucleoside bonds, uridine is formed, and its triphosphate compound is uridine, which is a precursor of uracil in the biosynthesis process of ribonucleic acid. Urine triphosphate participates as a coenzyme in the synthesis of certain sugars. Uracil can block the degradation of tegafur, increase the concentration of fluorouracil, and enhance its anti-cancer effect. The clinical indications are the same as that of fluorouracil, which is mainly used for digestive system cancer, breast cancer, thyroid cancer, etc., and the combination of mitomycin C and fluorouracil is effective for advanced gastric cancer. The laboratory obtained uracil by cyclization of urea with ethyl formate. Used for pharmaceutical and biochemical research.
