Food additives

Natamycin CAS 7681-93-8

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Natamycin CAS 7681-93-8

Natamycin, also known as horse horse mold or swimming mold, was first isolated from Streptomyces natalis in 1955 and its activity is much better than that of sorbic acid. In June 1982, the US FDA officially approved natamycin as a food preservative and classified it as a GRAS product. Natamycin is a highly effective inhibitor of mold, yeast, and fungi used to inhibit mold, yeast, and fungi in food. It is safe, reliable, and does not affect product flavor. It is widely used in foods such as cheese, meat products, pastries, and juices worldwide. This product is refined by deep fermentation and multi-step extraction of streptomycin, and its formulation is made by mixing 50% natamycin and 50% lactose.

Natamycin has a strong inhibitory effect on molds, yeasts, and fungi, but has no inhibitory effect on other microorganisms such as bacteria and viruses. Natamycin has a certain ability to resist heat treatment, is relatively stable in a dry state, and can withstand short-term high temperatures (100 ℃); However, due to its cyclic chemical structure and sensitivity to ultraviolet radiation, it is not suitable for contact with sunlight. The anchor stability of natamycin activity is affected by pH value, temperature, light intensity, oxidants, and heavy metals, so the product should avoid contact with oxides and sulfur compounds.

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Natamycin CAS 7681-93-8


Almost odorless white to creamy yellow crystalline powder, with stable crystal form of natamycin. The solubility in water and most organic solvents is very low. At room temperature, 1 liter of pure water can dissolve about 50mg, and low solubility is very suitable for surface treatment of food. When the pH is below 3 or above 9, the solubility of natamycin increases significantly, but its stability also decreases accordingly. In some organic solvents, natamycin has slightly higher solubility, reaching the solubility level, such as n-butanol, propylene glycol, etc., but it is necessary to consider whether these solvents can be used in the production of food. Natamycin can effectively inhibit almost all molds and yeasts. Li Dong (2004) studied the MIC of natamycin, which was 0.63mg/kg for Aspergillus, 1.8mg/kg for Aspergillus niger, and 4.5mg/kg for Aspergillus flavus. Most yeast strains are inhibited at a concentration of 1-5 mg/kg. The MIC value of natamycin can only be described as stunning. Most chemical preservatives that can inhibit mold require a lot of addition to achieve their antibacterial effect, resulting in significantly higher MIC values.

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