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Lidocaine CAS 137-58-6

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Lidocaine CAS 137-58-6 

Summary

Lidocaine exerts local anesthesia by reversibly blocking sodium channels and blocking the transmission of action potentials on nerve fibers. The sensory nerve fibers are blocked earlier than the motor nerve fibers, so low-dose lidocaine can exert selective sensory blockade. Lidocaine also has antiarrhythmic effects and belongs to Class Ib antiarrhythmic drugs. It can reduce ventricular rate, shorten action potential time and absolute refractory period, and prolong relative refractory period. Lidocaine has a fast onset and short duration of action. Adding adrenaline to lidocaine can reduce systemic absorption rate, thereby prolonging anesthesia time.

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Application
Lidocaine is a first-line medication for the treatment of ventricular arrhythmias caused by acute and severe hemodynamic abnormalities. It is also effective for some supraventricular arrhythmias, such as bypass mediated supraventricular tachycardia and acute episodes or parasympathetic mediated atrial fibrillation cardioversion. Widely used for surface anesthesia of mucous membranes (such as before endotracheal intubation). EMLA cream is used for skin surface anesthesia before intravenous catheterization surgery. To ensure the anesthesia effect, it is necessary to apply it to the skin for 45-60 minutes and wrap it with an airtight dressing to promote absorption. EMLA is very useful for rabbit ear vein catheterization and young dog and cat vein catheterization.

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